registration number: fb16-0033-wmz-2024
Entry date:
as soon as possible
Application deadline:
2025-01-05
Salary:
E 13 TV-H
Duration:
3 years
Volume of employment:
part-time (65 %)
The University of Marburg, founded in 1527, offers a variety of excellent programs of study for around 22,000 students and confronts the important topics of our time through excellent research across a broad spectrum of sciences.
At the Department of Pharmacy, Institute of Pharmaceutical Chemistry, RNA biochemistry, research group of Dr. Benedict Tan, is currently accepting applications for a
This project is funded by the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG). The position is offered for a period of 3 years and is conducted part-time (65 % of regular working hours) with salary and benefits commensurate with a public service position in the state Hesse, Germany (TV-H E 13, 65 %). The starting date is as soon as possible.
Mitochondria, the powerhouses of the cell, contain its own unique genome (mtDNA), whose gene products are essential for life. To match the energy requirements of specific cell types (e.g., neurons, cardiomyocytes), the expression of mitochondrial genes must be tightly and dynamically regulated, but our understanding of this process is still naïve.
In this project, we will investigate how the first two steps of mitochondrial gene expression (transcription and RNA processing) are mechanistically coupled, and how defects to this process contribute to a variety of rare and incurable human diseases. We will do this using sophisticated biochemical methods that reconstitute specific steps of mitochondrial RNA metabolism in vitro, using purified mitochondrial proteins. We will also study whether unique RNA structures in specific mitochondrial genes can regulate mitochondrial RNA processing. Through this, we aim to generate robust__ platforms with which we can design and screen highly-specific drugs to treat mitochondrial disease. Join our vibrant RNA community and build a network of interdisciplinary collaborations!
Further information can be found here: bit.ly/tanlabmarburg
The position is limited to a time period deemed adequate for the completion of a doctoral degree. As part of the assigned duties, there will be ample opportunity to conduct the independent scientific research necessary for the completion of a doctorate. The limitation complies to § 2, 1 WissZeitVG.
Disposition to own scientific qualification is expected.
We actively support the professional development of junior researchers by courses offered by the Marburg Research Academy (MARA), the International Office and the Higher Education Didactics Office.
+49 6421-28 25876
ben.tan@uni-marburg.de
We support women and strongly encourage them to apply. In areas where women are underrepresented, female applicants will be preferred in case of equal qualifications. As a certified family-friendly university, we support our employees in balancing family and career. A reduction of working time is possible. Applicants with a disability as discribed in SGB IX (§ 2 Abs. 2, 3) will be preferred in case of equal qualifications. Application and interview costs can not be refunded.
Please apply including a Letter of motivation (1 page), curriculum Vitae (2 pages), the contact details of at least 2 referees (reference letters are not required) and academic certificates by 3rd January 2025 using the application button below. All applications should be made in English.